Longevity Research Peptides • Mitochondrial Research Peptides
MOTS-C 10mg
$36.00$36.00
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MOTS-c is a synthetic 16-amino-acid peptide corresponding to a mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S ribosomal RNA gene, first characterized in the laboratory of Pinchas Cohen at the USC Leonard Davis School of Gerontology (CAS 1627580-64-6, MW ~2174.5 g/mol). Supplied as a ≥99% HPLC-UV purity lyophilized powder, 10 mg labeled size, with identity confirmed by LC-MS across four convergent charge states ([M+2H]²⁺, [M+3H]³⁺, [M+4H]⁴⁺, [M+5H]⁵⁺). Lot-specific Certificate of Analysis from Freedom Diagnostics (USA). Research Use Only — not for human or veterinary use.
Size
10mg
40mg
Compound Name
MOTS-c
Full Name
Mitochondrial Open reading frame of the Twelve S rRNA - c
Synonyms / Also Known As
MOTSc; MOTS c; Mitochondrial-derived peptide MOTS-c; 12S rRNA-encoded MDP
CAS Number
1627580-64-6
Molecular Formula
C₁₀₀H₁₄₆N₃₀O₂₂S₂
Molecular Weight
~2174.5 g/mol
Peptide Length
16 amino acids
Sequence (one-letter)
MRWQEMGYIFYPRKLR
Sequence (three-letter)
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
MS Confirmation on COA
Convergent identity confirmation across 4 charge states — [M+5H]⁵⁺ observed at m/z 435.900, [M+4H]⁴⁺ at 544.600, [M+3H]³⁺ at 725.700, [M+2H]²⁺ at 1088.500 (all back-calculating to ~2174.5 Da)
Origin (identity fact)
Encoded within the human mitochondrial 12S ribosomal RNA gene; one of the earliest characterized mitochondrial-derived peptides (MDPs)
Compound Class
Synthetic mitochondrial-derived peptide (MDP) referenced in biochemistry research
Product Type
Peptide
Purity
99.45% (HPLC-UV) — per COA lot MOTS-210-TPL
Identity Confirmation
Confirmed by LC-MS (per lot COA)
Appearance
White lyophilized powder
Solubility
Water-soluble
Available Sizes
10mg or 40mg
Net Content per Vial (COA)
11.14 mg or 44.56 mg
Storage (lyophilized)
-20°C, sealed, protected from light/moisture
Storage (reconstituted)
2–8°C short-term; aliquot & freeze -20°C; avoid freeze-thaw
Synthesis
Solid-phase peptide synthesis (SPPS)
Testing Lab
Freedom Diagnostics, USA
Principal Chemist (on COA)
Alex Johnson
Test Methods
Purity by HPLC with UV detection; identity by LC-MS
Lot Number
MOTS-210-TPL
Accession Number (COA)
2605280457
Shipped From
USA
Certificate of Analysis
Lot-specific COA available
For laboratory research use only. Not for human or veterinary
consumption. This product should only be handled by qualified
professionals.
Product information
MOTS-c — full name “Mitochondrial Open reading frame of the Twelve S rRNA – c” — is a synthetic 16-amino-acid peptide corresponding to a mitochondrial-derived peptide (MDP) that is encoded within a short open reading frame in the human mitochondrial 12S ribosomal RNA gene. MDPs are peptides whose coding sequences are found within mitochondrial DNA rather than in nuclear DNA, and MOTS-c is among the earliest such peptides to be characterized. The peptide was first identified and characterized in the laboratory of Pinchas Cohen at the USC Leonard Davis School of Gerontology. The peptide has a molecular weight of approximately 2174.5 g/mol and CAS number 1627580-64-6, with the one-letter sequence MRWQEMGYIFYPRKLR. On the lot referenced here (MOTS-210-TPL), identity is confirmed by LC-MS through convergent observation across four charge states — [M+5H]⁵⁺ at m/z 435.900, [M+4H]⁴⁺ at 544.600, [M+3H]³⁺ at 725.700, and [M+2H]²⁺ at 1088.500 — each back-calculating to the expected ~2174.5 Da mass. Documented purity by HPLC with UV detection is 99.45%. Third-party characterization was performed by Freedom Diagnostics (USA). This product is supplied as a white lyophilized powder at 10 mg labeled size (11.14 mg net content per vial per the COA), synthesized by solid-phase peptide synthesis (SPPS). It is intended exclusively for in-vitro laboratory research and analytical applications. In the research literature, MOTS-c is referenced as a synthetic mitochondrial-derived peptide used as a reference compound in biochemistry research on the MDP class.